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Two major groups were identified by principal component, phylogenetic, and identity by descent (IBD) analysis: Middle Eastern Jews and European/Syrian Jews.

The IBD segment sharing and the proximity of European Jews to each other and to southern European populations suggested similar origins for European Jewry and refuted large-scale genetic contributions of Central and Eastern European and Slavic populations to the formation of Ashkenazi Jewry.

Rapid decay of IBD in Ashkenazi Jewish genomes was consistent with a severe bottleneck followed by large expansion, such as occurred with the so-called demographic miracle of population expansion from 50,000 people at the beginning of the 15th century to 5,000,000 people at the beginning of the 19th century.

Thus, this study demonstrates that European/Syrian and Middle Eastern Jews represent a series of geographical isolates or clusters woven together by shared IBD genetic threads." "The genetic, cultural and religious traditions of contemporary Jewish people originated in the Middle East over three thousand years ago.

S1)." Excerpts from page 16223: "The higher diversity in the AJ population was paralleled by a lower inbreeding coefficient, F, indicating the AJ population is more outbred than Europeans, not inbred, as has long been assumed (P "Through genomic analysis, researchers at Emory University School of Medicine have shown that the Ashkenazi Jewish population is genetically more diverse than people of European descent, despite previous assumptions that Ashkenazi Jews have been an isolated population.

'Previous genetic studies of blood group and serum markers suggested that Jewish groups had Middle Eastern origin with greater genetic similarity between paired Jewish populations,' says senior study author, Dr. 'More recent studies of Y chromosomal and mitochondrial DNA have pointed to founder effects of both Middle Eastern and local origin, yet, the issue of how to characterize Jewish people as mere coreligionists or as genetic isolates that may be closely or loosely related remained unresolved. Yet the genomes of the Jewish Diaspora groups have distinctive features that are representative of each group's genetic history.' says Dr. 'Our study demonstrated that the studied Jewish populations represent a series of geographical isolates or clusters with genetic threads that weave them together,' added Dr. The researchers identified distinct Jewish population clusters that each exhibited a shared Middle Eastern ancestry, proximity to contemporary Middle Eastern populations and variable degrees of European and North African genetic intermingling. The two major groups, Middle Eastern Jews and European Jews, were timed to have diverged from each other approximately 2500 years ago.

Moreover, we also show that admixture directly correlates with high LD, suggesting that admixture has increased both genetic diversity and LD in the AJ population.

Additionally, we applied extended haplotype tests to determine whether positive selection can account for the level of AJ-prevalent diseases.

The pay-off will be Mc Cain having Lieberman as his running mate or appointing Lieberman to a key cabinet position.

Family Tree DNA: Genetic Testing Service Get genetically tested to discover your relationship to other families, other Jews, and other ethnic groups. Abstract: "The Ashkenazi Jewish (AJ) population has long been viewed as a genetic isolate, yet it is still unclear how population bottlenecks, admixture, or positive selection contribute to its genetic structure.

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